Pilnest and NEWEST Lip are next-generation polynucleotide injectable treatments — derived from ultra-purified salmon DNA — that repair tissue, stimulate collagen and improve skin quality from within. Provided by Clare Hird, nurse prescriber, with mobile appointments across Oxfordshire and the Cotswolds.
Pilnest Eyes or Face £250 · Course of 3 £675 · NEWEST Lip £275 · Course of 3 £700
Plinest is a line of injectable polynucleotide (PN-HPT) skin boosters designed to repair tissue, boost collagen and improve elasticity at a cellular level. Derived from ultra-purified salmon DNA, Plinest stimulates fibroblasts — the cells responsible for producing collagen and elastin — to rejuvenate the face, neck, scalp and body from within.
PN-HPT (Polynucleotide High Purification Technology) refers to the advanced purification process used to produce Plinest, which removes impurities and ensures maximum biological activity and tolerability. Unlike some polynucleotide products, Plinest is designed specifically for high performance tissue repair and regeneration at a cellular level, making it one of the most clinically targeted polynucleotide treatments available.
NEWEST is a variation within the Plinest range that includes hyaluronic acid (HA) and Mannitol alongside the core polynucleotide complex. While Plinest works at a cellular level to stimulate fibroblasts and trigger bio-revitalisation, the addition of HA and Mannitol in NEWEST takes this further — enhancing hydration beneath the skin surface, providing improved lift and boosting skin radiance. This makes NEWEST particularly well suited to patients with dry, dehydrated or wrinkled skin where additional moisture and volume support are needed alongside regeneration.
Like all Plinest products, NEWEST promotes bio-revitalisation to reverse signs of ageing. The HA and Mannitol do not work in isolation — they support and amplify the regenerative process triggered by the polynucleotides, adding volume and moisture to complement the collagen and elastin stimulation happening at a deeper level.
NEWEST Lip applies this same dual-action technology specifically to the lips and perioral area. It improves the quality, plumpness and definition of the lip itself rather than simply adding filler volume — making it ideal for those whose lips have thinned with age, or who want a natural improvement in lip quality without the added projection of traditional filler.
Pilnest and NEWEST Lip suit those wanting advanced skin regeneration with minimal downtime. NEWEST Lip is particularly suited to those wanting lip improvement without volume addition.
Clare uses Pilnest for the face and eye area, and NEWEST Lip for the lip and perioral zone. A course of 3 treatments is recommended for each, spaced 4–6 weeks apart. Clare often combines these treatments with other skin quality treatments for a comprehensive programme. NEWEST Lip can be used alongside lip filler for clients who want both improved lip quality and added volume.
Polynucleotide treatments are among the best-tolerated injectable treatments available.
Avoid make-up, sun exposure and active skincare for 24 hours. Keep lips moisturised after NEWEST Lip treatment. Avoid very hot or spicy food immediately after lip treatment. Results develop gradually over 6–8 weeks.
Lip filler adds crosslinked hyaluronic acid to physically increase volume and shape the lip. NEWEST Lip works differently — its polynucleotide complex stimulates bio-revitalisation of the lip tissue itself, while the HA and Mannitol add hydration and support from within. The result is a naturally plumper, more radiant and healthier lip, rather than a filled or projected one. It's ideal for those who want quality and condition improvement rather than added size.
Yes — polynucleotides including Pilnest and NEWEST are derived from fish DNA. Clare will take a full allergy history at consultation and will not treat patients with known fish or seafood allergies.
Clare recommends a course of 3 sessions, 4–6 weeks apart, for optimal results. A single maintenance session every 6 months thereafter.
Yes — the perioral area (around the lips) is one of the most effective areas for polynucleotide treatment. NEWEST Lip can visibly improve the fine lines above and around the mouth.
Pilnest is £200 per session; NEWEST Lip is £175. Courses of 3 are available with savings. Full pricing is on the pricing page.
Clare provides Pilnest and NEWEST Lip treatments for patients across Oxfordshire, including Oxford, Witney, Woodstock, Bicester, Chipping Norton and surrounding areas. Selected appointments are also available across the Cotswolds. All treatments are provided on a mobile basis — Clare comes to you.
As an independent nurse prescriber with Level 7 training in aesthetic medicine, Clare brings clinical rigour and a genuinely individualised approach to every treatment plan.
All consultations are relaxed, informative and completely no-obligation. Clare will assess your suitability and answer any questions you have before any decision is made.
Book a Consultation in Oxfordshire